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izvor podataka: crosbi

Nm23-H1 promotes adhesion of CAL 27 cells in vitro (CROSBI ID 147197)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bago, Ružica ; Pavelić, Jasminka ; Maravić Vlahoviček, Gordana ; Herak Bosnar, Maja Nm23-H1 promotes adhesion of CAL 27 cells in vitro // Molecular carcinogenesis, 48 (2009), 9; 779-789. doi: 10.1002/mc.20536

Podaci o odgovornosti

Bago, Ružica ; Pavelić, Jasminka ; Maravić Vlahoviček, Gordana ; Herak Bosnar, Maja

engleski

Nm23-H1 promotes adhesion of CAL 27 cells in vitro

nm23-H1 was found to diminish metastatic potential of carcinoma cell lines and therefore was placed in the group of metastatic suppressor genes. Its protein product has a function of a nucleosid-diphosphate kinase (NDPK) as well as protein kinase and nuclease. Though it was found that nm23-H1 is involved in many cellular processes, it is still not known how it promotes metastatic suppressor activity. Since the process of metastasis is dependent on adhesion properties of cells, the goal of our work was to describe the adhesion properties of CAL 27 cells (oral squamous cell carcinoma of the tongue) overexpressing FLAG/nm23-H1. In our experiments, cells overexpressing nm23-H1 show reduced migratory and invasive potential. Additionally, cells overexpressing Nm23-H1 adhere stronger on substrates (collagen IV and fibronectin) and show more spread morphology than the control cells. Results obtained by EGF induction of migration revealed that the adhesion strength predetermined cell response to chemoattractant and that Nm23-H1, in this cell type, does not interfere with, EGF induced, Ras signaling pathway. These data contribute to the overall knowledge about nm23-H1 and its role in cell adhesion, migration and invasion, especially in oral squamous cell carcinoma.

adhesion ; CAL 27 ; migration ; nm23 ; OSCC

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Podaci o izdanju

48 (9)

2009.

779-789

objavljeno

0899-1987

1098-2744

10.1002/mc.20536

Povezanost rada

Temeljne medicinske znanosti

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