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Pregled bibliografske jedinice broj: 379803

Ekspresija koštanih morfogenetskih proteina, hrskavičnih morfogenetskih proteina i njihovih receptora u osteoartritičnoj i zdravoj zglobnoj hrskavici


Bobinac, Dragica; Španjol, Josip; Marinović, Marin; Zoričić Cvek, Sanja; Marić, Ivana; Cicvarić, Tedi; Fučkar, Dora; Markić, Dean; Vojniković, Božidar
Ekspresija koštanih morfogenetskih proteina, hrskavičnih morfogenetskih proteina i njihovih receptora u osteoartritičnoj i zdravoj zglobnoj hrskavici // Collegium Antropologicum, 32 (2008), Suppl. 2; 83-87 (međunarodna recenzija, članak, znanstveni)


Naslov
Ekspresija koštanih morfogenetskih proteina, hrskavičnih morfogenetskih proteina i njihovih receptora u osteoartritičnoj i zdravoj zglobnoj hrskavici
(Expression of bone morphogenetic proteins, cartilage-derived morphogenetic proteins and related receptors in normal and osteoarthritic human articular cartilage)

Autori
Bobinac, Dragica ; Španjol, Josip ; Marinović, Marin ; Zoričić Cvek, Sanja ; Marić, Ivana ; Cicvarić, Tedi ; Fučkar, Dora ; Markić, Dean ; Vojniković, Božidar

Izvornik
Collegium Antropologicum (0350-6134) 32 (2008), Suppl. 2; 83-87

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Koštani morfogenetski proteini; hrskavični morfogenetski proteini; zglobna hrskavica
(Bone morphogenetic proetins; cartilage-derived morphogenetic proteins; articular cartilage)

Sažetak
Newborn and adult articular cartilage express bone (BMPs) and cartilage-derived morphogenetic proteins (CDMPs). These morphogenetic proteins act over membrane receptors (BMPRs). We examined the expression pattern of BMP-7, BMP-3, CDMP-1, CDMP-2 and their receptors in adult normal and osteoarthritic articular knee cartilage. Immunostaining was carried out using polyclonal antibodies. The expression of BMP-7, -3, CDMP-1, -2 was detected in all layers of normal articular cartilage with the strongest expression in chondrocytes of the transitional layer. BMP-7 and CDMPs expression decreased in osteoarthritic articular cartilage. BMPR-IB was not expressed in osteoarthritic cartilage. BMPs and CDMPs with intact signaling play an important role in articular cartilage homeostasis, preventing cartilage degeneration.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
062-0620226-0207 - Promjene koštanog metabolizma u bolestima bubrega i jetre (Dragica Bobinac, )
062-0620226-0209 - Koštani morfogenetski protein-7 i kost u modelu upalne bolesti crijeva (Ivana Marić, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE