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Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen


Šarić, Ana; Balog, Tihomir; Sobočanec, Sandra; Kušić, Borka; Šverko, Višnja; Rusak, Gordana; Likić, Saša; Bubalo, Dragan; Pinto, Barbara; Reali, Daniela; Marotti, Tatjana
Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen // Food and Chemical Toxicology, 47 (2009), 3; 547-554 doi:10.1016/j.fct.2008.12.007 (međunarodna recenzija, članak, znanstveni)


Naslov
Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen

Autori
Šarić, Ana ; Balog, Tihomir ; Sobočanec, Sandra ; Kušić, Borka ; Šverko, Višnja ; Rusak, Gordana ; Likić, Saša ; Bubalo, Dragan ; Pinto, Barbara ; Reali, Daniela ; Marotti, Tatjana

Izvornik
Food and Chemical Toxicology (0278-6915) 47 (2009), 3; 547-554

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antioxidants; Cystus incanus L. bee pollen; flavonoids; gene expression; lipid

Sažetak
 Oxidant/antioxidant status, estrogenic/anti-estrogenic activity and gene expression profile were studied in mice fed with Cystus incanus L. (Cistaceae) reach bee pollen from location in Central Croatia's Dalmatia coast and offshore islands. Seven phenolic compounds (out of thirteen tested) in bee pollen sample were detected by high performance liquid chromatography (HPLC) analysis. Phenolics detected in Cystus incanus L. bee pollen belong to flavonol (pinocembrin), flavanols (quercetin, kaempferol, galangin, isorhamnetin), flavones (chrysin) and phenylpropanoids (caffeic acid). Bee pollen as a food supplement (100 mg/kg bw mixed with commercial food pellets) compared to control (commercial food pellets) modulated antioxidant enzymes (AOE) in the mice liver, brain and lysate of erythrocytes and reduced hepatic lipid peroxidation (LPO). Bee pollen induced 25% of anti-estrogenic properties while no estrogenic activity was found. Differential gene expression profile analyses after bee pollen enriched diet identify underexpressed gene Hspa9a, Tnfsf6 (liver) and down-regulated gene expression of Casp 1 and Cc121c (brain) which are important in the apoptosis pathway and chemotaxis. These results indicate that used bee pollen possess a noticable source of compounds with health protective potential and antioxidant activity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-1647 - Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu (Tihomir Balog, )
119-1191192-1213 - Flavonoidi i molekularni mehanizmi njihovih bioloških učinaka (Gordana Rusak, )
178-0000000-3580 - Palinološke odlike nektara i meda od ljekovite kadulje (Salvia officinalis) (Dragan Bubalo, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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