engleski

Diabetic nephropathy with focal segmental glomerulosclerosis

The association of diabetic nephropathy with primary glomerulonephritis is rare. Several reports have shown that primary glomerulonephritis can be superimposed on diabetic nephropathy. These glomerulonephritis include idiopathic membranous glomerulonephritis, IgA glomerulonephritis, Henoch- Schonlein nephritis, membranoproliferative glomerulonephritis, lupus nephritis, minimal change disease, postinfectious glomerulonephritis and rapidly progressive glomerulonephritis. Because some of these disorders can alter the management and prognosis of renal disease in diabetic patients, the appearance of urinary abnormalities (hematuria, atypical nephrotic syndrome) or deterioration in renal function inconsistent with the natural history of diabetic nephropathy raises the possibility of a nondiabetic renal disease and should lead to a more detailed evaluation. We report a patient with type I diabetes that underwent a renal biopsy because of the heavy proteinuria and nephrotic syndrome. Renal biopsy showed diabetic nephropathy coexistent with focal segmental glomerulosclerosis. To the best of our knowledge, this is the first reported case of primary focal segmental glomerulosclerosis associated with diabetic nephropathy and diabetic retinopathy, with excellent therapeutic response.

Glomerulosclerosis focal-complications ; Glomerulosclerosis focal-diagnosis ; Glomerulosclerosis focal-therapy ; Diabetic nephropathies-diagnosis ; Diabetic nephropathies-immunology ; Diabetic nephropathies-therapy ; Kidney ; glomerules-pathology

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