engleski

Structural abnormalities of chromosome 1 in acute myeloid leukemia with lymph node involvment

A younger male patient presented with acute leukemia of myeloid morphology (M2) with unusual clinical presentation of affection of lymphatic nodes, mediastinum and spleen. Immunophenotypicaly same antigen expression on blasts was found in BM, PB and biopsized lymph node. Cytogentics detected 46, xy, der (1) hsr(1 ; 1)(p11 ; ?)+6, del(6))p21=, -13, add(17p). Highly unusal and extensive involvment of chromosome 1 material in this complex karyotype suggest that some of the abberant genetic information related to Chromosome 1 in this patients might be responible for unusual hematological behaviour of the tumour

Chromosome 1 ; myeoloid leukemia ; lymphoid involvment

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