engleski

Is quadrant biopsy adequate as first-line sampling scheme in men likely to have non-organ-confined prostate cancer:comparasion to extended biopsy protocol

Background. While extensive prostate biopsy (PB) in the patients with early prostate cancer (PC) provides better sensitivity and more precise tumor staging, in the patients with advanced PC, it is virtualy only a confirmation of malignancy. The purpose of our study was to find out wether the quadrant prostate biopsy (QPB) provides a suficient first-line pathological evaluation in the patients likely to have advanced PC, and whether the reduction of core number impairs the competence pf PB through missing quantitative histology information. Methods.We studied 84 men who underwent PB and classified into groups "H" (highly-)and "L" (low likely to have advanced PC). Pathological results of 5-12 cores PB and stimulated QPB were retrosectively compared, particulary for the presence pf PC, tumor volume, Gleason score (GS), and the presence of high-grade prostatic intraepithelial neoplasia (HGPIN). Results. The PC detection rate was not impaired in group H, but dropped significantly in group L, while the percentage of positive cores was insignificantly changed in group H (p=0, 39), but significantly decreased in group L (p=0.04) due to the sampling scheme reduction. No HGPIN was missed with QBP in group H, while 2 HGPIN were missed in group L. Insignificant GS changes resulted in both groups as a consequence of the limitation to QPB. Conclusions. QPB is an appropiate first-line scheme in the patients with advanced PC as the information lost due to the core number reduction is mainly not critical for patinet management.

prostatic neoplasma-pathology; biopsy; needle; prostate-specific antigen

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