engleski

Antidepressant-mediated cortisol and prolactin release in nonpsychotic depressed patients

Plasma cortisol and prolactin concentrations were determined by RIA at 8,9,10 and 11 a.m. in nonpsychotic drug-free depressed female patients after acute challenge with paroxetine (20 or 40 mg), reboxetine (4 mg), imipramine (50 mg) or placebo administered after blood sampling at 8 a.m. Plasma cortisol, in contrast to plasma prolactin, showed circadian variations, with the highest values at 8 a.m. and lowest values at 11 a.m. in all groups except reboxetine-treated. These data show that serotoninergic antidepressants (paroxetine and imipramine), in contrast to noradrenergic antidepressant reboxetine, did not alter a normal cortisol decline induced by circadian variations. Plasma cortisol levels in reboxetine treated group differed significantly when compared to control group ( depressed patients on placebo) at 10 and 11 a.m. Plasma prolactin levels differed only in imipramine treated group, with a significant fall at 11 a.m. when comapred to 8 a.m. These data suggest that noradrenergic, rather than serotoninergic system, might be involved in the control of cortisol release, while both systems seem to be responsible for the regulation of prolactin release in depressed patients.

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