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Breast infiltrating ductal carcinoma: analysis of hormone, HER-2 receptors and Ki-67 proliferation marker


Mustać, Elvira; Zamolo, Gordana; Petković, Marija; Đorđević, Gordana; Radić, Jelena; Grgurević, Emina; Batinac, Tanja
Breast infiltrating ductal carcinoma: analysis of hormone, HER-2 receptors and Ki-67 proliferation marker // Collegium antropologicum, 32 (2008), 741-746 (međunarodna recenzija, članak, znanstveni)


Naslov
Breast infiltrating ductal carcinoma: analysis of hormone, HER-2 receptors and Ki-67 proliferation marker

Autori
Mustać, Elvira ; Zamolo, Gordana ; Petković, Marija ; Đorđević, Gordana ; Radić, Jelena ; Grgurević, Emina ; Batinac, Tanja

Izvornik
Collegium antropologicum (0350-6134) 32 (2008); 741-746

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Karcinom dojke; hormonski receptori; menopauzalni status; HER-2; Ki67
(Breast carcinoma; hormone receptors; menopausal status; HER-2; Ki67)

Sažetak
The aim of this study was to analyse breast carcinomas with discordant receptor status, probably hormonal dependent (estrogen receptor (ER) positive, progesterone receptor (PR) negative or ER-PR + subgroup profile) infiltrating ductal breast carcinomas not otherwise specified (IDC NOS). Specimens from 90 IDC NOS were grouped into three categories according to hormonal status: dependent (D) (ER +PR +), probably dependent (PD) (ER +PR- or ER-PR +) and non-dependent (ND) (ER-PR-) ; they were evaluated considering some established prognostic parameters in breast carcinomas. Statistically significant difference was found between tumor receptor status distribution and menopausal status (p = 0.0235), age of the patients (p = 0.000467), histological grade (p = 0.000003), vascular invasion (p = 0.006), HER-2 status (p = 0.0039) and Ki-67 proliferation rate (p = 0.000311). D tumors were found exclusively in post-menopausal patients (average age 68.9 years), most of which had intermediate (II) grade, without vascular invasion, with HER-2 status score predominantly 0 or 1 + and lower Ki-67 proliferation rate. PD tumors were found predominantly in younger post-menopausal patients (average age 57.5 years), with vascular invasion found in 23% of the cases. ND tumors mostly had higher histological grade, showed the highest percentage of the Ki-67 positive tumor cells and vascular invasion in 30% of the cases. We conclude that the patients with PD breast carcinomas were younger post-menopausal women with the tumors moderately differentiated, HER-2 score 0 or 1+ and with lower Ki-67 proliferation rate.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
062-0620095-0077 - Molekularni mehanizmi tumorske progresije i metastaziranja raka dojke i prostate (Elvira Mustać, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE