Enzyme-Catalysed Nucleophilic Ring Opening of Epoxides for the Preparation of Enantiopure Tertiary Alcohols (CROSBI ID 146100)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Majerić Elankov, Maja ; Hoeffken, Wolfgang H. ; Tang, Lixia ; Hauer, Bernhard ; Janssen, Dick B.
engleski
Enzyme-Catalysed Nucleophilic Ring Opening of Epoxides for the Preparation of Enantiopure Tertiary Alcohols
The halohydrin dehalogenase from Agrobacterium radiobacter AD1 catalyzes nucleophilic ring opening of epoxides with cyanide and azide. In the case of 2, 2-disubstituted epoxides, this reaction proceeds with excellent enantioselectivity (E values up to>200), which gives, by kinetic resolution, access to various enantiopure epoxides and b-substituted tertiary alcohols (ee up to 99%). Since the enzyme has a broad substrate range and because these tertiary alcohols are difficult to prepare in other ways, HheC is an attractive biocatalyst for the production of b-cyano and b-azido tertiary alcohols.
azides ; cyanides ; epoxides ; halohydrin dehalogenase ; tertiary alcohols
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Podaci o izdanju
349 (14-15)
2007.
2279-2285
objavljeno
1615-4150
1615-4169
10.1002/adsc.200700146