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Pregled bibliografske jedinice broj: 374971

Reversible brain atrophy in patients with Cushing's disease


Gnjidić, Živko; Sajko, Tomislav; Kudelić, Nenad; Malenica, Maša; Vizner, Branka; Vrkljan, Milan; Hat, Josip; Rumboldt, Zoran
Reversible brain atrophy in patients with Cushing's disease // Collegium antropologicum, 32 (2008), 4; 1165-1170 (međunarodna recenzija, članak, znanstveni)


Naslov
Reversible brain atrophy in patients with Cushing's disease

Autori
Gnjidić, Živko ; Sajko, Tomislav ; Kudelić, Nenad ; Malenica, Maša ; Vizner, Branka ; Vrkljan, Milan ; Hat, Josip ; Rumboldt, Zoran

Izvornik
Collegium antropologicum (0350-6134) 32 (2008), 4; 1165-1170

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cushing’ s disease ; brain atrophy ; pituitary ACTH adenoma ; hypercortisolism ; transsphenoidal surgery ; CT ; MRI ; reversibility

Sažetak
During the past 25 years, we came across 60 patients with corticotroph pituitary adenomas and Cushing’ s disease. Neuroradiological examination showed prominent volume loss of the brain parenchyma, unexpected for the patient’ s age. This » brain atrophy« appeared to regress after surgical removal of pituitary adenoma and normalization of cortisol level. Observed difference between degree of » brain atrophy« in the Cushing’ s disease group and in the control group was statistically significant (p<0.001). The degree of » brain atrophy« correlated well with the duration of Cushing’ s disease. Partial reversibility of » brain atrophy« was noticed during the 2nd, 3rd and 4th year after surgery and normalization of cortisol level. Increased cortisol level is one of the causative factors in pathogenesis of » brain atrophy« . Loss of brain volume is at least partially reversible after normalization of cortisol levels.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2394 - Gensko liječenje tumora djelovanjem na molekule imunološkog sustava (Jasminka Pavelić, )
098-0982464-2527 - Genetska podloga razvitka tumora hipofize (Živko Gnjidić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Živko Gnjidić (autor)

Avatar Url Josip Hat (autor)

Avatar Url Zoran Rumboldt (autor)

Avatar Url Tomislav Sajko (autor)

Avatar Url Maša Malenica (autor)

Avatar Url Branka Vizner (autor)

Avatar Url Milan Vrkljan (autor)

Citiraj ovu publikaciju

Gnjidić, Živko; Sajko, Tomislav; Kudelić, Nenad; Malenica, Maša; Vizner, Branka; Vrkljan, Milan; Hat, Josip; Rumboldt, Zoran
Reversible brain atrophy in patients with Cushing's disease // Collegium antropologicum, 32 (2008), 4; 1165-1170 (međunarodna recenzija, članak, znanstveni)
Gnjidić, Ž., Sajko, T., Kudelić, N., Malenica, M., Vizner, B., Vrkljan, M., Hat, J. & Rumboldt, Z. (2008) Reversible brain atrophy in patients with Cushing's disease. Collegium antropologicum, 32 (4), 1165-1170.
@article{article, year = {2008}, pages = {1165-1170}, keywords = {Cushing’ s disease, brain atrophy, pituitary ACTH adenoma, hypercortisolism, transsphenoidal surgery, CT, MRI, reversibility}, journal = {Collegium antropologicum}, volume = {32}, number = {4}, issn = {0350-6134}, title = {Reversible brain atrophy in patients with Cushing's disease}, keyword = {Cushing’ s disease, brain atrophy, pituitary ACTH adenoma, hypercortisolism, transsphenoidal surgery, CT, MRI, reversibility} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE