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Pregled bibliografske jedinice broj: 372853

Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells


Horvat, Štefica; Kralj, Marijeta; Perc, Milica; Jerić, Ivanka; Varga-Defterdarović, Lidija; Jakas, Andreja; Roščić, Maja; Šuman, Lidija; Gredičak, Matija
Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells // Chemical biology & drug design, 73 (2009), 2; 253-257 doi:10.1111/j.1747-0285.2008.00763.x (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 372853 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells

Autori
Horvat, Štefica ; Kralj, Marijeta ; Perc, Milica ; Jerić, Ivanka ; Varga-Defterdarović, Lidija ; Jakas, Andreja ; Roščić, Maja ; Šuman, Lidija ; Gredičak, Matija

Izvornik
Chemical biology & drug design (1747-0277) 73 (2009), 2; 253-257

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Leu-enkephalin ; Met-enkephalin ; Opioid peptides ; In vitro antiproliferative activity ; Peptide synthesis ; Analogues

Sažetak
A series of new backbone-modified Leu- and Met-enkephalin analogues (13-20 a and b) were synthesized. Backbone manipulations involved the replacement of the Gly2 residue in Tyr-Gly-Gly-Phe-Leu/Met with side-chain glucosylated or adamantylated D/L-aspartic or -glutamic acids. The in vitro antiproliferative activity of these compounds was evaluated for several cell lines and the results were compared with the effect of Met-enkephalin, the native opioid growth factor (OGF). The tested compounds modestly inhibited the growth of the tumor cells (20-50% inhibition at millimolar concentrations). Among the tested compounds, Tyr-D-Glu(AdNH)-Gly-Phe-Met (20b) showed significant antiproliferative activity, somewhat more pronounced on MCF-7 (breast carcinoma) and MOLT-4 (lymphoblastic leukemia) cells.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Kralj, Marijeta, MZOS ) ( POIROT)
098-0982933-2936 - Kemijske preobrazbe prirodnih spojeva (Varga-Defterdarović, Lidija, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Horvat, Štefica; Kralj, Marijeta; Perc, Milica; Jerić, Ivanka; Varga-Defterdarović, Lidija; Jakas, Andreja; Roščić, Maja; Šuman, Lidija; Gredičak, Matija
Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells // Chemical biology & drug design, 73 (2009), 2; 253-257 doi:10.1111/j.1747-0285.2008.00763.x (međunarodna recenzija, članak, znanstveni)
Horvat, Š., Kralj, M., Perc, M., Jerić, I., Varga-Defterdarović, L., Jakas, A., Roščić, M., Šuman, L. & Gredičak, M. (2009) Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells. Chemical biology & drug design, 73 (2), 253-257 doi:10.1111/j.1747-0285.2008.00763.x.
@article{article, year = {2009}, pages = {253-257}, DOI = {10.1111/j.1747-0285.2008.00763.x}, keywords = {Leu-enkephalin, Met-enkephalin, Opioid peptides, In vitro antiproliferative activity, Peptide synthesis, Analogues}, journal = {Chemical biology and drug design}, doi = {10.1111/j.1747-0285.2008.00763.x}, volume = {73}, number = {2}, issn = {1747-0277}, title = {Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells}, keyword = {Leu-enkephalin, Met-enkephalin, Opioid peptides, In vitro antiproliferative activity, Peptide synthesis, Analogues} }
@article{article, year = {2009}, pages = {253-257}, DOI = {10.1111/j.1747-0285.2008.00763.x}, keywords = {Leu-enkephalin, Met-enkephalin, Opioid peptides, In vitro antiproliferative activity, Peptide synthesis, Analogues}, journal = {Chemical biology and drug design}, doi = {10.1111/j.1747-0285.2008.00763.x}, volume = {73}, number = {2}, issn = {1747-0277}, title = {Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells}, keyword = {Leu-enkephalin, Met-enkephalin, Opioid peptides, In vitro antiproliferative activity, Peptide synthesis, Analogues} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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