Homocysteine and serum lipids concentration in male war veterans with posttraumatic stress disorder (CROSBI ID 145720)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Jendričko, Tihana ; Vidović, Anđelko ; Grubišić- Ilić, Mirjana ; Romić, Željko ; Kovačić, Zrnka ; Kozarić-Kovačić, Dragica
engleski
Homocysteine and serum lipids concentration in male war veterans with posttraumatic stress disorder
The evidence of increased cardiovascular disease (CVD) risk in posttraumatic stress disorder (PTSD) is accumulating. The present study aimed to determine whether chronic, combat-related PTSD is associated with serum lipid and homocysteine concentrations that could indicate higher CVD risk. The authors tested 66 war veterans with PTSD, 33 war veterans without PTSD, and 42 healthy volunteers for serum concentrations of homocysteine, total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglycerides. All the subjects were men and the analyses were adjusted for age, body mass index and smoking. Potential influences of depression, anxiety, and psychotic symptoms on the outcome measures were checked by introducing the scores from the Hamilton Depression Rating Scale (HAM-D-17), the Hamilton Anxiety Scale (HAMA), and the Positive and Negative Syndrome Scale (PANSS) into the overall statistical model. No differences in total cholesterol, LDL-C, HDL-C and triglycerides were found between the groups. Non-smoking PTSD war veterans had higher homocysteine concentrations (mean = 10.4 µ ; mol/L, SD = 1.7) when compared to non-smoking war veterans without PTSD (mean = 8.2 µ ; mol/L, SD = 4.0, P = 0.014) and both smoking (mean = 8.7 µ ; mol/L, SD = 2.3, P = 0.008) and non-smoking healthy volunteers (mean = 8.8 µ ; mol/L, SD = 2.2, P = 0.021). The results of our cross-sectional study are possibly confounded by many factors, especially behavioral and life-style related which are difficult to control comprehensively
posttraumatic stress disorder ; homocysteine ; lipids
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Podaci o izdanju
33 (1)
2009.
134-140
objavljeno
0278-5846
1878-4216
10.1016/j.pnpbp.2008.11.002
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti