engleski

Human papillomaviruses in lesions of the oral mucosa

Human papillomaviruses are considered to initiate epithelial proliferation and contribute in the development of benign, premalignant and malignant oral lesions. the purpose of this study was to investigate the frequency of HPV in morphologically different oral lesions.The study included a total of 120 subjects of which 26 with erosive-ulcerous lesions and 94 with different proliferative oral lesions including keratotic, hyperplastic and warty lesions. Oral cytological samples were collected from each lesion and HPV DNA was detectedby polymerase chain reaction (PCR) as previously described (Grce, M. et al. Anticancer Res 21:579 ; 2001).The presence of HPV DNA was detected in 28 of 120 (23, 3%) oral samples of which 5 of 26 (19, 2%) and 23 of 94 (24, 5) in patients with erosive-ulcerous lesions and proliferative lesions, respectively.HPV is probably associated with the development of hyperkeratotic and hyperplastic oral lesions. Additionaly damaged oral mucosa increases the risk of HPV infection. HPV DNA positive oral lesions need to be continuosly followed up and if necessary treated to avoid malignant outcome.

papillomaviruses ; oral mucosa ; oral lesions

Oral Diseases, Volume 14, Issue s1: Special Issue: Abstracts of the 9th Biennial Congress of the European Association of Oral Medicine, 18‐20