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Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder (CROSBI ID 145696)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Hercigonja Novković, Vesna ; Rudan, Vlasta ; Pivac, Nela ; Nedić, Gordana ; Muck-Šeler, Dorotea Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder // Neuropsychobiology, 59 (2009), 1; 17-22. doi: 10.1159/000202825

Podaci o odgovornosti

Hercigonja Novković, Vesna ; Rudan, Vlasta ; Pivac, Nela ; Nedić, Gordana ; Muck-Šeler, Dorotea

engleski

Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric disorder highly prevalent in children. The neurobiology of ADHD is still not clear, but is assumed to be related to disturbances in catecholaminergic and serotonergic (5-hydroxytryptamine, 5-HT) systems. Peripheral indices of central 5-HT function were shown by recent studies to be lower, unaltered, or increased in ADHD. The study determined platelet 5-HT concentration in 84 medication-free 9 years-old (range 4-14 years) boys and girls with DSM-IV diagnosis of ADHD, subdivided according to the different symptoms (inattention, hyperactivity, and impulsivity) and clinical ADHD subtypes (predominantly hyperactive, predominantly inattentive, and combined subtype), and in 30 age and sex-matched healthy controls. Children with ADHD had similar platelet 5-HT concentrations as control children. Platelet 5-HT concentration did not differ between boys and girls, and between children with a hyperactive, inattentive, and combined subtype of ADHD. In children with ADHD there was a significant positive correlation between platelet 5-HT concentration and impulsive symptoms, but not with symptoms of inattention or hyperactivity. Platelet 5-HT concentration was significantly higher in impulsive compared to non-impulsive children with ADHD. The data provide preliminary evidence that increased platelet 5-HT concentration in impulsive children with ADHD might be a trait marker, predictive of impulsivity in ADHD.

attention-deficit/hyperactivity disorder; children; platelet serotonin; impulsivity

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Podaci o izdanju

59 (1)

2009.

17-22

objavljeno

0302-282X

10.1159/000202825

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

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