Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 37230

Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates


Smital, Tvrtko; Sauerborn, Roberta; Pivčević, Branka; Krča, Sanja; Kurelec, Branko
Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates // Comparative Biochemistry and Physiology C, 126 (2000), 175-186 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 37230 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates

Autori
Smital, Tvrtko ; Sauerborn, Roberta ; Pivčević, Branka ; Krča, Sanja ; Kurelec, Branko

Izvornik
Comparative Biochemistry and Physiology C 126 (2000); 175-186

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Accumulation; Aquatic invertebrates; Cyclosporin A; Efflux; Pollution; Rhodamine; Species-specific MXR activity; Verapamil

Sažetak
The presence and function of the P-glycoprotein mediated multixenobiotic resistance (MXR) mechanism was demonstrated in numerous aquatic organisms. The aim of this study was to investigate whether in aquatic organisms exists the inherent, species-specific basal level of MXR activity. Here are presented the results of the direct comparison of the basal (noninduced) level of MXR activity measured in several marine (Mytilus galloprovincialis, Monodonta turbinata, Patella lusitanica) and freshwater (Dreissena polymorpha, Viviparus viviparus, Anodonta cygnea) molluscs species. The primary criterion for the assessment and quantification of the basal level of MXR activity was the ratio (R) between the accumulation or efflux of the fluorescent model MXR substrates (rhodamine B or rhodamine 123) in or from the gills, measured with and in the absence of model MXR inhibitors verapamil or cyclosporin A. Significantly different levels of MXR activity were found in the species investigated. These levels generally show a relatively good correlation with the level of pollution present in their natural habitats. Considering these results a conclusion was reached that in aquatic organisms indeed exist the different inherent, species-specific levels of MXR activity. The identified levels might be, at least partly, responsible either for the resistance to, or for the sensitivity of a particular species to organic pollution.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
00981510

Ustanove:
Institut "Ruđer Bošković", Zagreb


Citiraj ovu publikaciju:

Smital, Tvrtko; Sauerborn, Roberta; Pivčević, Branka; Krča, Sanja; Kurelec, Branko
Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates // Comparative Biochemistry and Physiology C, 126 (2000), 175-186 (međunarodna recenzija, članak, znanstveni)
Smital, T., Sauerborn, R., Pivčević, B., Krča, S. & Kurelec, B. (2000) Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates. Comparative Biochemistry and Physiology C, 126, 175-186.
@article{article, year = {2000}, pages = {175-186}, keywords = {Accumulation, Aquatic invertebrates, Cyclosporin A, Efflux, Pollution, Rhodamine, Species-specific MXR activity, Verapamil}, journal = {Comparative Biochemistry and Physiology C}, volume = {126}, title = {Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates}, keyword = {Accumulation, Aquatic invertebrates, Cyclosporin A, Efflux, Pollution, Rhodamine, Species-specific MXR activity, Verapamil} }
@article{article, year = {2000}, pages = {175-186}, keywords = {Accumulation, Aquatic invertebrates, Cyclosporin A, Efflux, Pollution, Rhodamine, Species-specific MXR activity, Verapamil}, journal = {Comparative Biochemistry and Physiology C}, volume = {126}, title = {Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates}, keyword = {Accumulation, Aquatic invertebrates, Cyclosporin A, Efflux, Pollution, Rhodamine, Species-specific MXR activity, Verapamil} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI





Contrast
Increase Font
Decrease Font
Dyslexic Font