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Pregled bibliografske jedinice broj: 372263

Nonspecific interactions in spontaneous assembly of empty versus functional single-stranded RNA viruses


Šiber, Antonio; Podgornik, Rudolf
Nonspecific interactions in spontaneous assembly of empty versus functional single-stranded RNA viruses // Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 78 (2008), 5 Part 1; 051915-1 doi:10.1103/PhysRevE.78.051915 (međunarodna recenzija, članak, znanstveni)


Naslov
Nonspecific interactions in spontaneous assembly of empty versus functional single-stranded RNA viruses

Autori
Šiber, Antonio ; Podgornik, Rudolf

Izvornik
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics (1539-3755) 78 (2008), 5 Part 1; 051915-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Virus; protein; ssRNA; assembly; electrostatic

Sažetak
We investigate the influence of salt concentration, charge on viral proteins and the length of single-stranded RNA (ssRNA) molecule on the spontaneous assembly of viruses. Only the nonspecific interactions are assumed to guide the assembly, i.e., we exclude any chemical specificity that may lock the viral proteins and ssRNA in preferred configurations. We demonstrate that the electrostatic interactions screened by the salt in the solution impose strong limits on viral composition that can be achieved by spontaneous assembly. In particular, we show that viruses whose ssRNA carries more than twice the amount of charge that is located on the viral proteins, cannot be assembled spontaneously. We find that the spatial distribution of protein charge is important for the energetics of the assembly. We also show that the pressures that act on the viruses as a result of attractive protein-ssRNA electrostatic interactions are at least an order of magnitude smaller than is the case with bacteriophage viruses that contain double-stranded DNA molecule.

Izvorni jezik
Engleski

Znanstvena područja
Fizika



POVEZANOST RADA


Projekt / tema
035-0352828-2837 - Energetskom kompeticijom uvjetovani oblici i strukture nanometarskih sustava (Antonio Šiber, )

Ustanove
Institut za fiziku, Zagreb

Autor s matičnim brojem:
Antonio Šiber, (226073)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • INSPEC


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