engleski

Relevance of HPV diagnostic procedures

Persistent infection with certain types of the Human papillomavirus (HPV) is the necessary cause for cervical cancer. HPV DNA is identified in almost all cases of cervical cancer worldwide. More than 100 HPV genotypes have been characterized with approximately 40 types infecting the human anogenital area. About 13 of these (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 66) are strongly associated with the development of cervical precancerous lesions and cancer and have been designated as the HR-HPV types. In contrast HPV 6, 11, and some others genital HPV types are associated with benign genital warts but not cervical cancer and have been classified as low-risk (LR). Cervical cancer is highly amenable to screening because it has a long pre-clinical phase with precursor lesions that can be identified by cervical cytology and easily treated using simple outpatient procedures if they are detected at an early stage. HPV DNA testing plays an important role in diagnosis, treatment and follow-up of women with cervical abnormalities. In addition, HPV DNA testing is also a useful tool in monitoring other, although rare, anogenital lesions in men and women.

Human papillomavirus

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