engleski

Five-membered [C, N] and [N, O] metallocyclic complexes of palladium(II) with monoalkyl [alpha-(4-benzeneazoanilino)-N-benzyl]phosphonates : synthesis, characterization and antitumor activity

The synthesis, spectroscopic and biological properties of the novel palladium(II) complexes with monoethyl (HL1) and monobutyl (HL2) ester of [alpha-[(4-benzeneazoanilino)-N-benzyl]phosphonic acid, have been prepared and studied. These potential polydentate ligands form two types of metallocyclic compounds, those with [C, N] and [N, O] five-membered chelate ring. The former are cyclopalladated chloro-bridged binuclear complexes in which the deprotonated ligand undergoes palladation at the azo nitrogen and the ortho-carbon, while the latter mononuclear complexes contain the organophosphorus ligand bonded through the aniline nitrogen and the deprotonated phosphonic acid oxygen. The complexes were identified and characterized by elemental analysis, magnetic and conductance measurements as well as by infrared, 1H, 13C and 31P nuclear magnetic resonance and ESI-mass spectroscopic studies. The in vitro antitumor activity of all the complexes was evaluated against human KB cell line as a preliminary screening for their biological activity. The coordination behaviour of monoalkyl benzeneazophosphonates as well as the spectral and biological properties of their complexes were compared with the results reported for the corresponding dialkyl phosphonates and their palladium(II) complexes.

palladium(II) complexes; metallocycles; aminophosphonate complexes; spectroscopy; antitumor activity

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