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izvor podataka: crosbi

mRNA expression of serotonin receptors in cells of the immune tissues of the rat (CROSBI ID 85781)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Štefulj, Jasminka ; Jernej, Branimir ; Čičin-Šain, Lipa ; Rinner, Ingo ; Schauenstein, Konrad mRNA expression of serotonin receptors in cells of the immune tissues of the rat // Brain, behavior, and immunity, 14 (2000), 3; 219-224. doi: 10.1006/brbi.1999.0579

Podaci o odgovornosti

Štefulj, Jasminka ; Jernej, Branimir ; Čičin-Šain, Lipa ; Rinner, Ingo ; Schauenstein, Konrad

engleski

mRNA expression of serotonin receptors in cells of the immune tissues of the rat

Serotonin (5-hydroxytryptamine, 5-HT) has been shown to play a role in immunoregulation; however, little is known about specific subtypes of 5-HT receptors involved in peripheral immunomodulation. In the present study we used RT-PCR methods to examine the mRNA expression of 5-HT receptors in the cells of lymphoid tissues of the rat. All thirteen rat 5-HT receptor genes cloned so far were examined in ex vivo isolated spleen, thymus and peripheral blood lymphocytes, as well as in mitogen stimulated spleen cells. Positive signals were obtained for 5-HT1B, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT6 and 5-HT7 receptor mRNAs in all three compartments. Mitogen (ConA and PWM) stimulated spleen cells additionally expressed mRNA corresponding to the 5HT-3 receptor subtype. In contrast, 5-HT1A, 5-HT1D, 5-HT2C, 5-HT4, 5-HT5A and 5-HT5B mRNAs were not detected in any of the examined cell populations. These results may be useful as a starting point for future functional studies on immunomodulatory effects of 5-HT, and may help to understand conflicting serotonergic effects on immune functions as found in the literature.

serotonin; 5-HT receptor mRNA; immune tissues; lymphocytes; mitogen stimulation

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Podaci o izdanju

14 (3)

2000.

219-224

objavljeno

0889-1591

1090-2139

10.1006/brbi.1999.0579

Povezanost rada

Temeljne medicinske znanosti

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