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Xenobiotic clenbuterol in food producing male pigs: Various tissue residue accumulation on days after withdrawal


Gojmerac, Tihomira; Pleadin, Jelka; Bratoš, Igor; Vulić, Ana; Vahčić, Nada
Xenobiotic clenbuterol in food producing male pigs: Various tissue residue accumulation on days after withdrawal // Meat science, 80 (2008), 879-884 doi:10.1016/j.meatsci.2008.04.013 (međunarodna recenzija, članak, znanstveni)


Naslov
Xenobiotic clenbuterol in food producing male pigs: Various tissue residue accumulation on days after withdrawal

Autori
Gojmerac, Tihomira ; Pleadin, Jelka ; Bratoš, Igor ; Vulić, Ana ; Vahčić, Nada

Izvornik
Meat science (0309-1740) 80 (2008); 879-884

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Clenbuterol; β 2-adrenergic agonist residues; food producing pigs
(Clenbuterol; β a-Adrenergic agonist residues; food producing pigs)

Sažetak
Using enzyme-linked immunosorbent assay (ELISA) and liquid chromatography tandem mass spectrometry (LC-MS/MS) the concentrations of clenbuterol (ng/g) were shown to be highest in choroid/pigmented retinal epithelium (choroid/PRE) (499.59± ; 26.36 ng/g), followed by hair (fair colored) (207.76± ; 86.88 ng/g), liver (25.06± ; 16.72 ng/g) and kidney (6.88± ; 3.52 ng/g) after 28 days of oral clenbuterol administration in a growth-promoting dose (10 μ g/kg BW, twice daily) to food producing male pigs, with a high correlation coefficient between the two methods for all study matrices (r=0.8800-0.9999). In the liver as an alimentary tissue and regulatory matrix for the control of clenbuterol abuse, the maximal allowed concentration of 0.5 ng/g was achieved by clenbuterol depletion from liver tissue (0.40± ; 0.12 ng/g) on day 14 and in the kidney (0.28± ; 0.10 ng/g) on day 7 of treatment withdrawal. In contrast, the concentration of residual clenbuterol in choroid/PRE (57.49± ; 6.13 ng/g) and hair (68.36± ; 3.35 ng/g) recorded on day 14 of treatment withdrawal was 143- and 170-fold that measured in the liver, with a similar ratio persisting on day 35 of treatment withdrawal (164:1 and 183:1, respectively). These findings indicated a high accumulation potential of clenbuterol residues in the hair and choroid/PRE as compared with the liver and kidney, pointing to the pig choroid/PRE and hair as useful new matrices in the control of clenbuterol abuse as a growth promotant in food production, especially after prolonged withdrawal.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
048-0531854-0467 - Ostaci kemijskih kontaminanata u hrani: Farmakokinetika i toksikologija (Dražen Oraić, )

Ustanove
Hrvatski veterinarski institut, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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