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Pregled bibliografske jedinice broj: 369048

The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations


Džimbeg, Gabrijela; Zorc, Branka; Kralj, Marijeta; Ester, Katja; Pavelić, Krešimir; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations // European journal of medicinal chemistry, 43 (2008), 6; 1180-1187 doi:10.1016/j.ejmech.2007.09.001 (međunarodna recenzija, članak, znanstveni)


Naslov
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations

Autori
Džimbeg, Gabrijela ; Zorc, Branka ; Kralj, Marijeta ; Ester, Katja ; Pavelić, Krešimir ; Andrei, Graciela ; Snoeck, Robert ; Balzarini, Jan ; De Clercq, Erik ; Mintas, Mladen

Izvornik
European journal of medicinal chemistry (0223-5234) 43 (2008), 6; 1180-1187

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antiviral agents; Antitumoral agents; Primaquine; Biologically active compounds; Urea

Sažetak
The novel urea primaquine derivatives 3a– i were prepared by aminolysis of benzotriazolide 2 with the corresponding amine in the presence or absence of triethylamine. Compound 2 was prepared by acylation of primaquine with 1-benzotriazole carboxylic acid chloride. Among all compounds evaluated, the pyridine derivative 3h exhibited the best cytostatic activities against colon carcinoma, human T-lymphocyte and murine leukemia. However, this compound showed also rather marked cytotoxicity towards human normal fibroblasts. The highest selectivity in the inhibitory effects on human malignant tumor cell lines vs. normal fibroblasts was found for ureas 3c, 3d and 3g. Results of broad antiviral evaluation showed that pyridine and phenethyl derivatives of urea 3h and 3g exhibited some selective inhibition against cytomegalovirus.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, )
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mladen Mintas, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE
  • Scopus
  • Elsevier BIOBASE
  • Current Awareness in Biological Sciences


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