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Pregled bibliografske jedinice broj: 369038

Fenoprofen and ketoprofen amides as potential antitumor agents


Marjanović Marko; Zorc, Branka; Pejnović, Lana; Zovko, Marijana; Kralj, Marijeta
Fenoprofen and ketoprofen amides as potential antitumor agents // Chemical biology & drug design, 69 (2007), 3; 222-226 doi:10.1111/j.1747-0285.2007.00494.x (međunarodna recenzija, članak, znanstveni)


Naslov
Fenoprofen and ketoprofen amides as potential antitumor agents

Autori
Marjanović Marko ; Zorc, Branka ; Pejnović, Lana ; Zovko, Marijana ; Kralj, Marijeta

Izvornik
Chemical biology & drug design (1747-0277) 69 (2007), 3; 222-226

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antiproliferative effect; apoptosis; cell cycle arrest; fenoprofen; fenoprofenamides; human tumor cell lines; ketoprofen; ketoprofenamides; lipophilicity

Sažetak
Following numerous experimental observations that various non-steroidal anti-inflammatory drugs have antitumor potentials, a series of fenoprofenamides (1a– g) and ketoprofenamides (2a– c) was tested on proliferation of different human tumor cell lines and normal human fibroblasts in vitro. Fenoprofen and ketoprofen showed modest antiproliferative activity, whereas the growth inhibitory activity of the tested amides clearly demonstrates that the substituents linked by an amide bond are essential for the significantly stronger cytostatic activity, probably because of a greater lipophilicity and/or better cell uptake. Additionally, it was shown that the most active derivatives (1d and 2a) induced cell cycle arrest at the G1 phase, as well as apoptosis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, )
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Marjanović Marko; Zorc, Branka; Pejnović, Lana; Zovko, Marijana; Kralj, Marijeta
Fenoprofen and ketoprofen amides as potential antitumor agents // Chemical biology & drug design, 69 (2007), 3; 222-226 doi:10.1111/j.1747-0285.2007.00494.x (međunarodna recenzija, članak, znanstveni)
Marjanović Marko, Zorc, B., Pejnović, L., Zovko, M. & Kralj, M. (2007) Fenoprofen and ketoprofen amides as potential antitumor agents. Chemical biology & drug design, 69 (3), 222-226 doi:10.1111/j.1747-0285.2007.00494.x.
@article{article, year = {2007}, pages = {222-226}, DOI = {10.1111/j.1747-0285.2007.00494.x}, keywords = {antiproliferative effect, apoptosis, cell cycle arrest, fenoprofen, fenoprofenamides, human tumor cell lines, ketoprofen, ketoprofenamides, lipophilicity}, journal = {Chemical biology and drug design}, doi = {10.1111/j.1747-0285.2007.00494.x}, volume = {69}, number = {3}, issn = {1747-0277}, title = {Fenoprofen and ketoprofen amides as potential antitumor agents}, keyword = {antiproliferative effect, apoptosis, cell cycle arrest, fenoprofen, fenoprofenamides, human tumor cell lines, ketoprofen, ketoprofenamides, lipophilicity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE
  • Biochemistry & Biophysics Citation Index
  • Index Chemicus


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