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Developmental and transplacental genotoxicology: Fluconazole


Fučić, Aleksandra; Marković, Darko; Herceg, Zdenko; Gamulin, Marija; Katić, Jelena; Stojković, Ranko; Ferenčić, Željko; Mildner, Boris; Jazbec Ana-Marija; Dobranić Tomislav
Developmental and transplacental genotoxicology: Fluconazole // Mutation research. Genetic toxicology and environmental mutagenesis, 657 (2008), 1 Special Issue; 43-47 doi:10.1016/j.mrgentox.2008.08.008 (međunarodna recenzija, članak, znanstveni)


Naslov
Developmental and transplacental genotoxicology: Fluconazole

Autori
Fučić, Aleksandra ; Marković, Darko ; Herceg, Zdenko ; Gamulin, Marija ; Katić, Jelena ; Stojković, Ranko ; Ferenčić, Željko ; Mildner, Boris ; Jazbec Ana-Marija ; Dobranić Tomislav

Izvornik
Mutation research. Genetic toxicology and environmental mutagenesis (1383-5718) 657 (2008), 1 Special Issue; 43-47

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Fluconazole; transplacental genotoxicology; development; micronucleus assay; systems biology

Sažetak
Over the last 40 years mankind has been facing new types of radiochemical environmental settings with every decade. During the last decade, biomonitoring was additionally focused on assessing associations between environmental exposure(s) and both early and late biological effects in children. Despite efforts to control and avoid child exposure to genotoxic agents the incidence of childhood cancers is increasing. Some cancers in adulthood may be the consequence of a multi-step process which starts with intrauterine and childhood exposure. This highlights the importance of a comprehensive interpretation of multiple health effects, especially considering recent studies suggesting that most health disorders are related to DNA changes. When exposed to genotoxic agents, a developing organism (fetus or child) is constantly being forced to reorganize into new equilibriums in order to adjust to a xenobiotic environment. In addition, the influence of sex hormones on radiochemical sensitivity is still unknown. For this reason special attention should be paid to puberty. The results of recent studies on animal models and follow up studies on children after nuclear accidents show long-lasting cytogenetic damage even after low dose exposures and their transgenerational persistance. To evaluate age-related difference and transplacental genotoxic potency fluconazole (FC) was investigated by in vivo micronucleus (MN) assay in adult mice, young mice and in transplacentally exposed newborn pups. Compared to the baseline values, FC caused no detectable genome damage in adult animals, but there was a significant increase in MN frequency in young animals and in newborn pups. Our study thus exemplifies an age- related chemosensitivity, and argues that cancer- promoting disturbances of complex prenatal developmental mechanisms and maturation during childhood require a new approach using systems biology.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Veterinarska medicina



POVEZANOST RADA


Projekt / tema
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Vilena Kašuba, )
098-0982464-2390 - Novi terapijski modaliteti u liječenju malignih bolesti (Ranko Stojković, )
108-1080399-0335 - Eksperimentalni embrionalni tumori i razvoj zametaka sisavaca in vitro i in vivo (Florijana Jakuš, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Veterinarski fakultet, Zagreb,
Šumarski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Klinički bolnički centar Zagreb,
Fidelta d.o.o.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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