engleski

Diazene JK-279: potential anticancer drug

The aim of this study was to examine the cytotoxic effect of ten new synthesized diazenecarboxamides (diazenes). Using a modified colorimetric MTT assay, their cytotoxicity was determined on ten human cell lines: cervical carcinoma parental and cisplatin resistant cells, laryngeal carcinoma parental and cisplatin and vincristine resistant cells, glioblastoma parental and cisplatin resistant cells, breast adenocarcino-ma parental and doxorubicin resistant cells and mammary carcinoma cells. Results show that diazene JK-279 was most effective, reducing significantly the cell survival of all ten cell lines examined, including five drug-resistant cell lines. Cytotoxic effect was observed also on nine from ten cell lines for diazene JK-835. A small reduction in cell survival was obtained (mainly for highest drug concentrations) for diazenes LV-57 and MG-19 on two cell lines, and JK-429 and JK-913 on one cell line. Other diazenes did not demonstrate any cytotoxic activity. The results encourage further research on diazene JK-279 as a potential anticancer drug.

anticancer drugs; diazenes; tumor cells; drug-resistance

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