hrvatski

Indeks tjelesne mase kod bolesnika s pozitivnom dijagnozom ili sumnjom na koronarnu arterijsku bolest: veliko hrvatsko kohortno istraživanje

Background. BMI is one of the measures used in clinical epidemiological studies as well as in clinical diagnosis of obesity. Obesity and BMI have been implicated as independent risk factors for CAD. On contrary, the relationship between BMI and CAD may be absent or sometimes shows the “ obesity paradox” . The aim of the study presented was to determine the prevalence of BMI in Croatian patients with confirmed or suspected coronary artery disease. Materials and Methods. 728 Croatian patients who underwent coronary angiography were involved in the study. The concentrations of glucose, lipid parameters, homocysteine and fibrinogen were performed with standard methods. BMI was calculated after measurement of body weight and height. Results. There were no significant difference between three BMI-categories for CAD(+) and CAD(-) patients, neither for the patients with and without diabetes or smoking status. In CAD(+) group, relation between MI and BMI was absent, but there was significantly more obese patients with arterial hypertension (p=0.005). There were significant differences in plasma cholesterol (p=0.001), HDL-cholesterol (p<0.001), apolipoprotein A (p<0.001) and triacylglycerol (p=0.002) concentrations between normal, overweight and obese patients. This significances are clinically irrelevant because the observed differences are less than than 5%. According to significant correlation tests, HDL-cholesterol, Apo A-I, triacylglycerol and hypertension didn’ t’ match any relationship with BMI. Conclusions. BMI depends on lipid parameters as risk factor for CAD, although the CAD was not associated with BMI values in our study subjects. The absence of the relationship between BMI and CAD was observed.

insdeks tjelesne mase; koronarna arterijska bolest; čimbenici rizika

nije evidentirano

engleski

Body mass index in patients with positive or suspected coronary artery disease: large Croatian cohort

Background. BMI is one of the measures used in clinical epidemiological studies as well as in clinical diagnosis of obesity. Obesity and BMI have been implicated as independent risk factors for CAD. On contrary, the relationship between BMI and CAD may be absent or sometimes shows the “ obesity paradox” . The aim of the study presented was to determine the prevalence of BMI in Croatian patients with confirmed or suspected coronary artery disease. Materials and Methods. 728 Croatian patients who underwent coronary angiography were involved in the study. The concentrations of glucose, lipid parameters, homocysteine and fibrinogen were performed with standard methods. BMI was calculated after measurement of body weight and height. Results. There were no significant difference between three BMI-categories for CAD(+) and CAD(-) patients, neither for the patients with and without diabetes or smoking status. In CAD(+) group, relation between MI and BMI was absent, but there was significantly more obese patients with arterial hypertension (p=0.005). There were significant differences in plasma cholesterol (p=0.001), HDL-cholesterol (p<0.001), apolipoprotein A (p<0.001) and triacylglycerol (p=0.002) concentrations between normal, overweight and obese patients. This significances are clinically irrelevant because the observed differences are less than than 5%. According to significant correlation tests, HDL-cholesterol, Apo A-I, triacylglycerol and hypertension didn’ t’ match any relationship with BMI. Conclusions. BMI depends on lipid parameters as risk factor for CAD, although the CAD was not associated with BMI values in our study subjects. The absence of the relationship between BMI and CAD was observed.

body mass index; coronary artery disease; risk factors

nije evidentirano