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Pregled bibliografske jedinice broj: 367724

Chromosome patterns in children with acute nonlymphocytic leukemia at relapse


Petković, Iskra; Konja, Josip; Nakić, Melita
Chromosome patterns in children with acute nonlymphocytic leukemia at relapse // SIOP Abstract book 2008 International Society of Paediatric Oncology
Berlin, Germany, 2008. str. 123-123 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Chromosome patterns in children with acute nonlymphocytic leukemia at relapse

Autori
Petković, Iskra ; Konja, Josip ; Nakić, Melita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
SIOP Abstract book 2008 International Society of Paediatric Oncology / - , 2008, 123-123

Skup
40th Congress of the International Society of Paediatric Oncology

Mjesto i datum
Berlin, Germany, 02.-06.10.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Chromosome aberrations; acute nonlymphocytic leukemia; relapse

Sažetak
Purpose: In this work we present the results of cytogenetic analysis in 8 children with acute myeloid leukemia studied at relapse. The aim of this investigation was to obtain further data on acquired chromosome aberrations and their clinical implications in children with acute nonlymphocytic leukemia. Method: The investigation was performed on slides obtained from a 24- hour peripheral blood or bone marrow cultures. For chromosome identification GTG- and CBG-banding method were used. In 5 children the analysis was performed at diagnosis and at relapse, while in three patients at relapse. Results: In two children a normal diploid karyotype was found at both initial presentation and relapse, while clonal chromosomal aberrations were detected in 5 patients at relapse. We observed some recurrent chromosomal aberrations such as t(8 ; 21), deletion of the long arm of chromosome 11 and t(9 ; 22). Of special interest are structural rearrangements of chromosome 3, extremely rare rearrangement in children with acute myeloid leukemia. Conclusion: Our observation imply that additional studies are necessary in order to determine the frequency, clinical and prognostic significance of rare recurrent aberrations in children with AML. This work was supported by grant from Ministary of Science, Education and Sports in the Republic of Croata (Project No. 072-1083107-0361).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
072-1083107-0361 - Telomere i kromosomske aberacije u patologiji dječje dobi (Petković, Iskra, MZOS - )
108-0000000-0049 - Zloćudne bolesti u djece (Konja, Josip, MZOS - )

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Iskra Petković (autor)

Avatar Url Melita Nakić (autor)

Citiraj ovu publikaciju

Petković, Iskra; Konja, Josip; Nakić, Melita
Chromosome patterns in children with acute nonlymphocytic leukemia at relapse // SIOP Abstract book 2008 International Society of Paediatric Oncology
Berlin, Germany, 2008. str. 123-123 (poster, međunarodna recenzija, sažetak, znanstveni)
Petković, I., Konja, J. & Nakić, M. (2008) Chromosome patterns in children with acute nonlymphocytic leukemia at relapse. U: SIOP Abstract book 2008 International Society of Paediatric Oncology.
@article{article, year = {2008}, pages = {123-123}, keywords = {Chromosome aberrations, acute nonlymphocytic leukemia, relapse}, title = {Chromosome patterns in children with acute nonlymphocytic leukemia at relapse}, keyword = {Chromosome aberrations, acute nonlymphocytic leukemia, relapse}, publisherplace = {Berlin, Germany} }




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