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Pregled bibliografske jedinice broj: 366930

A Study of H-Bond in Group of NSAID Hydroxamic Acid Derivatives


Rajić, Zrinka; Jadrijević-Mladar Takač, Milena; Vinković, Marijana; Zorc, Branka; Takač, Vedran
A Study of H-Bond in Group of NSAID Hydroxamic Acid Derivatives // CEUM 2008 Book of Abstracts: The 10th Central European NMR Symposium & The 10th Central European Bruker NMR Users Meeting / Vilko Smrečki (ur.).
Zagreb: Ruđer Bošković Institute, 2008. str. 14-14 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 366930 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
A Study of H-Bond in Group of NSAID Hydroxamic Acid Derivatives

Autori
Rajić, Zrinka ; Jadrijević-Mladar Takač, Milena ; Vinković, Marijana ; Zorc, Branka ; Takač, Vedran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
CEUM 2008 Book of Abstracts: The 10th Central European NMR Symposium & The 10th Central European Bruker NMR Users Meeting / Vilko Smrečki - Zagreb : Ruđer Bošković Institute, 2008, 14-14

ISBN
978-953-6690-77-0

Skup
The 10th Central European NMR Symposium, & The 10th Central European Bruker NMR Users Meeting

Mjesto i datum
Zagreb, Hrvatska, 29-30.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Hydrogen bond; NSAID hydroxamic acis; NMR spectroscopy; one- and two-dimensional homo and heteronuclear 1H and 13C NMR; IR spectroscopy

Sažetak
The conformational behaviour of NSAID series (ibuprofen, fenprofen, ketoprofen, diclophenac and indomethacin) monohydroxamic acids and their intermediates have been studied in DMSO-d6 solution by one- and two-dimesional homo and heteronuclear 1H and 13C NMR spectroscopy and in solid state using FTIR spectroscopy. Significant hydrogen bonding effects were observed in both, solid state and solutions. The NMR spectra (1H and 13C NMR, COSY, NOESY, HMBC, HETCOR) revealed that investigated NSAID hydroxamic acids and their corresponding intermediates in DMSO solution are in keto form of cis-(Z) conformer with intramolecular hydrogen bond O-H...O= type. NMR findings observed in DMSO-d6 solution are in good agreement with FTIR of NSAID hydroxamic acids in solid state.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekt / tema
4858 - Spektroskopija NMR i modeliranje bioaktivnih molekula (Dejan Plavšić, MZOS)
3917 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, MZOS)
929 - Modeliranje molekula i materijala metodama matematičke i računarske kemije (Ante Graovac, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Rajić, Zrinka; Jadrijević-Mladar Takač, Milena; Vinković, Marijana; Zorc, Branka; Takač, Vedran
A Study of H-Bond in Group of NSAID Hydroxamic Acid Derivatives // CEUM 2008 Book of Abstracts: The 10th Central European NMR Symposium & The 10th Central European Bruker NMR Users Meeting / Vilko Smrečki (ur.).
Zagreb: Ruđer Bošković Institute, 2008. str. 14-14 (poster, međunarodna recenzija, sažetak, znanstveni)
Rajić, Z., Jadrijević-Mladar Takač, M., Vinković, M., Zorc, B. & Takač, V. (2008) A Study of H-Bond in Group of NSAID Hydroxamic Acid Derivatives. U: Vilko Smrečki (ur.)CEUM 2008 Book of Abstracts: The 10th Central European NMR Symposium & The 10th Central European Bruker NMR Users Meeting.
@article{article, year = {2008}, pages = {14-14}, keywords = {Hydrogen bond, NSAID hydroxamic acis, NMR spectroscopy, one- and two-dimensional homo and heteronuclear 1H and 13C NMR, IR spectroscopy}, isbn = {978-953-6690-77-0}, title = {A Study of H-Bond in Group of NSAID Hydroxamic Acid Derivatives}, keyword = {Hydrogen bond, NSAID hydroxamic acis, NMR spectroscopy, one- and two-dimensional homo and heteronuclear 1H and 13C NMR, IR spectroscopy}, publisher = {Ru\djer Bo\v{s}kovi\'{c} Institute}, publisherplace = {Zagreb, Hrvatska} }




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