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Pregled bibliografske jedinice broj: 366682

CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – In vitro evaluation using the PLHC-1 fish hepatoma cell line


Traven, Luka; Žaja, Roko; Lončar, Jovica; Smital, Tvrtko; Mićović, Vladimir
CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – In vitro evaluation using the PLHC-1 fish hepatoma cell line // Toxicology in vitro, 22 (2008), 6; 1648-1656 doi:10.1016/j.tiv.2008.06.012 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 366682 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – In vitro evaluation using the PLHC-1 fish hepatoma cell line

Autori
Traven, Luka ; Žaja, Roko ; Lončar, Jovica ; Smital, Tvrtko ; Mićović, Vladimir

Izvornik
Toxicology in vitro (0887-2333) 22 (2008), 6; 1648-1656

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CYP1A induction ; EROD ; PLHC-1 cells ; Marine sediments ; Priority pollutants

Sažetak
The use of in vitro biotests in combination with chemical determination of priority pollutants is considered a promising approach in environmental risk assessment. The main goal of this study was to evaluate the relationship between the CYP1A induction potential and the concentration of priority pollutants (PAHs, PCBs and heavy metals) in contaminated marine sediments. Six sediment samples characterized by different types of pollution were collected from the Bay of Kvarner, Croatia. CYP1A induction potency was determined in vitro by the measurement of ethoxyresorufin-O-deethylase (EROD) activity in PLHC-1 fish hepatoma cells. The results were compared to the potency of the model CYP1A inducer 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and expressed in 2, 3, 7, 8-TCDD equivalents. All of the tested sediment samples were able to induce CYP1A activity in a dose-dependent manner. On a general scale, there was a good correlation between CYP1A induction and the concentration of priority pollutants in the tested samples. However, some samples, which had relatively low levels of priority pollutants, exhibited a strong CYP1A induction response. Therefore, apart from the confirmed usability and sensitivity of the EROD determination in the PLHC-1 cells as a suitable in vitro model in ecotoxicology, the results of this study indicate that the list of priority pollutants usually determined in the attempt to evaluate the risk of adverse effects to marine wildlife should be reconsidered.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
062-0621341-0308 - Odgovor ljudi i morskih organizama na ekološko zagađenje u Kvarnerskom zaljevu (Mićović, Vladimir, MZOS ) ( POIROT)
098-0982934-2745 - Ekotoksikološko značenje ABC transportnih proteina u vodenih organizama (Smital, Tvrtko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Luka Traven (autor)

Avatar Url Roko Žaja (autor)

Avatar Url Jovica Lončar (autor)

Avatar Url Vladimir Mićović (autor)

Avatar Url Tvrtko Smital (autor)

Citiraj ovu publikaciju

Traven, Luka; Žaja, Roko; Lončar, Jovica; Smital, Tvrtko; Mićović, Vladimir
CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – In vitro evaluation using the PLHC-1 fish hepatoma cell line // Toxicology in vitro, 22 (2008), 6; 1648-1656 doi:10.1016/j.tiv.2008.06.012 (međunarodna recenzija, članak, znanstveni)
Traven, L., Žaja, R., Lončar, J., Smital, T. & Mićović, V. (2008) CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – In vitro evaluation using the PLHC-1 fish hepatoma cell line. Toxicology in vitro, 22 (6), 1648-1656 doi:10.1016/j.tiv.2008.06.012.
@article{article, year = {2008}, pages = {1648-1656}, DOI = {10.1016/j.tiv.2008.06.012}, keywords = {CYP1A induction, EROD, PLHC-1 cells, Marine sediments, Priority pollutants}, journal = {Toxicology in vitro}, doi = {10.1016/j.tiv.2008.06.012}, volume = {22}, number = {6}, issn = {0887-2333}, title = {CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – In vitro evaluation using the PLHC-1 fish hepatoma cell line}, keyword = {CYP1A induction, EROD, PLHC-1 cells, Marine sediments, Priority pollutants} }
@article{article, year = {2008}, pages = {1648-1656}, DOI = {10.1016/j.tiv.2008.06.012}, keywords = {CYP1A induction, EROD, PLHC-1 cells, Marine sediments, Priority pollutants}, journal = {Toxicology in vitro}, doi = {10.1016/j.tiv.2008.06.012}, volume = {22}, number = {6}, issn = {0887-2333}, title = {CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – In vitro evaluation using the PLHC-1 fish hepatoma cell line}, keyword = {CYP1A induction, EROD, PLHC-1 cells, Marine sediments, Priority pollutants} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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