engleski

The role of alphoid higher order repeats (HORs) in the centromere folding

Understanding the folding of centromere DNA in the maximally condensed metaphase chromosome remains a basic challenge in cell biology. We propose here a set of structural models with a graphical presentation of alphoid higher order repeat (HOR) distribution in the centromere folding, based on the assumption of encryption key for microtubule-centromere interaction which arises from chromosome-specific crystal-like structure of HORs. Specific HOR leads to a characteristic geometrical pattern which may be responsible for individual microtubule to recognize a specific structure of centromere in each chromosome.

DNA; centromere folding; higher order repeat

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