engleski

Catalytic Promiscuity of Halohydrin Dehalogenase and its Application in Enantioselective Epoxide Ring Opening

Halohydrin dehalogenase is a highly promiscuous enzyme that can catalyze enantioselective epoxide ring opening with at least nine different anionic nucleophiles. Its capacity to form carbon-nitrogen, carbon-oxygen, carbon-sulfur, and carbon-carbon bonds makes it possible to use this enzyme for the preparation of a range of highly enantioenriched beta-substituted alcohols or derivatives thereof, including cyanoalcohols, nitroalcohols, and oxazolidinones.

Biocatalysis; Enantioselectivity; Epoxides; Halohydrin dehalogenase; Nucleophiles

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