engleski

Evaluation of the combination of omeprazole and azithromycin with or without metronisazole in eradicating Helicobacter pylori

Purpose: We evaluated the benefit of 7 therapeutic achedules with omeprazole (OME) and azithromycin (AZ) with or without metronidazole (ME) for eradication of Helicobacter pylori. Methods: Helicobacter pylori status was determinated by rapid urease test and hystology before and 4 weeks or more after therapy. 7 groups of H. pylori infected patients with peptic ulcer disease were studied. Group 1 (n=25) and 2 (n=25) received OME 20mg/day for 14 days and AZ 500 mg/day for 5 days. Group 2 received and ME 3x500 mg/day for 5 days, Group 3, 4, 5, 6 and 7 received OME 40 mg/day for 14 days. Group 3 (n=16) received AZ 500 mg/day for 5 days. Group 4 (n=20) received AZ 500 mg/day for 9 days. Group 5 (n=20) received AZ 500 mg/day for 9 days and ME 3x500 mg/day for 7 days. Group 6 (n=19) received AZ 2x500 mg for 9 days. Group 7 (n=15) received AZ 2x5oo mg/day for 9 days and ME 3x500 mg/day for 7 days. Side effects were recorded in all patients. Results: The eradication rate in group 1, 2, 3, 4, 5, 6 and 7 was 64%, 72%, 62.5%, 70%, 75%, 73.7% and 86.6%. 21.4% (30/140) patients experienced minor or mild side effects, none discontinued therapy because of side effects. Conclusion: We conclude that omeprazole 40 mg/day for 14 days, azithromycin 2x5oo mg/day for 9 days and netronidazole 3x5oo mg/day for 7 days is effective treatment for eradication H. pylori infection.

Helicobacter pylori; therapy; eradication

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