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Biotransformation of 5alpha- and 5beta-androstane-3beta/3alpha, 17beta- -diols by human CYP3A4 and 2C19 enzymes (CROSBI ID 472400)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Rendić, Slobodan ; Nolteernsting, Eckhard ; Schanzer, Wilhelm Biotransformation of 5alpha- and 5beta-androstane-3beta/3alpha, 17beta- -diols by human CYP3A4 and 2C19 enzymes // ISSX Meeting / s.n. (ur.). Bethesda (MD): ISSX, 1999. str. 470-470-x

Podaci o odgovornosti

Rendić, Slobodan ; Nolteernsting, Eckhard ; Schanzer, Wilhelm

engleski

Biotransformation of 5alpha- and 5beta-androstane-3beta/3alpha, 17beta- -diols by human CYP3A4 and 2C19 enzymes

Cytochrome P450 (CYP) enzymes catalyze biotransformations of endogenous and exogenous steroids in regio- and stereoselective manner both in vitro and in vivo. Of the identified human CYP enzymes, the four subfamilies (CYP1A, CYP2B, CYP2C and CYP3A) catalyze hydroxylation of the steroids selectively at different positions (1-4). In the present study, 5?-androstane-3?/?,17?-diols, and 5?-androstane-3?,17?-diol were incubated with human recombinant CYP3A4 and CYP2C19 enzymes (PANVERA, USA). Structures of metabolites, as trimethylsilyl-ether derivatives, were determined by the GC/MS method, and the major metabolites were quantified (3,4). 5?-Dihydrotestosterone (5?-DHT) was formed selectively from 5?-androstane-3?,17?-diol by both CYP3A4 and CYP2C9 enzymes, higher level of formation was observed with the former enzyme.

cytochrome P450; CYP3A4; CYP2C9; CYP2C19; Human; Sterod hormones

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Podaci o prilogu

470-470-x.

1999.

objavljeno

Podaci o matičnoj publikaciji

ISSX Meeting

s.n.

Bethesda (MD): ISSX

Podaci o skupu

9th North American ISSX Meeting

poster

24.10.1999-28.10.1999

Nashville (TN), Sjedinjene Američke Države

Povezanost rada

Farmacija