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Genetic heterogeneity of L-Zagreb mumps virus vaccine strain


Košutić-Gulija, Tanja; Forčić, Dubravko; Šantak, Maja; Ramljak, Ana; Mateljak-Lukačević, Sanja; Mažuran, Renata
Genetic heterogeneity of L-Zagreb mumps virus vaccine strain // Virology Journal, 5 (2008), 79-1 doi:10.1186/1743-422X-5-79 (međunarodna recenzija, članak, znanstveni)


Naslov
Genetic heterogeneity of L-Zagreb mumps virus vaccine strain

Autori
Košutić-Gulija, Tanja ; Forčić, Dubravko ; Šantak, Maja ; Ramljak, Ana ; Mateljak-Lukačević, Sanja ; Mažuran, Renata

Izvornik
Virology Journal (1743-422X) 5 (2008); 79-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mumps; quasispecies; genetic heterogeneity; L-Zagreb strain

Sažetak
The most often used mumps vaccine strains Jeryl Lynn (JL), RIT4385, Urabe-AM9, L-Zagreb and L-3 differ in immunogenicity and reactogenicity. Previous analyses showed that JL, Urabe-AM9 and L-3 are genetically heterogeneous. We identified the heterogeneity of L-Zagreb throughout the entire genome. Two major variants were defined: variant A being identical to the consensus sequence of viral seeds and vaccine(s) and variant B which differs from variant A in three nucleotide positions. The difference between viral variants in L-Zagreb strain is insufficient for distinct viral strains to be defined. We demonstrated that proportion of variants in L-Zagreb viral population depends on cell substrate used for viral replication in vitro and in vivo. CL-Zagreb strain should be considered as a single strain composed of at least two variant viral genomes.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
021-0212432-3123 - Molekularna patogeneza virusa mumpsa (Maja Šantak, )

Ustanove
Imunološki zavod d.d.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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