Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 362097

Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients


Stipčević, Tamara; Kusačić-Kuna, Sanja; Deželjin, Martina; Dodig, Damir; Koršić, Mirko; Pivac, Nela; Muck-Šeler, Dorotea
Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients // Hormone research, 71 (2009), 4; 207-212 doi:10.1159/000201109 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 362097 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients

Autori
Stipčević, Tamara ; Kusačić-Kuna, Sanja ; Deželjin, Martina ; Dodig, Damir ; Koršić, Mirko ; Pivac, Nela ; Muck-Šeler, Dorotea

Izvornik
Hormone research (0301-0163) 71 (2009), 4; 207-212

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Platelet 5-HT ; Platelet MAO B ; hypothyroidism ; thyroxine ; thyroid stimulating hormone

Sažetak
The relationship between hypothalamic-pituitary-thyroid (HPT) axis and serotonergic (5-HT) system is not clear. The aim of the study was to determine platelet biochemical markers (5-HT concentration and monoamine oxidase /MAO-B/ activity) in hypothyroid patients. The study included 25 female medication-free hypothyroid patients in postoperative follow-up after total thyroidectomy due to papillary thyroid carcinoma, who were not treated with synthetic thyroxine (T4) for 4 weeks, and 44 age matched euthyroid healthy women. Platelet 5-HT concentration, platelet MAO-B activity, total T4 and thyroid stimulating hormone (TSH) levels were determined using spectrofluorimetric methods, radioimmunoassay and fluoroimmunoassay, respectively. Hypothyroid patients had significantly higher TSH, significantly lower T4 levels and platelet 5-HT concentration, and unchanged platelet MAO-B acrivity than healthy subjects. A positive correlation between 5-HT concentration and platelet MAO-B activity, and between platelet MAO-B activity and T4 in control subjects was found. Reduced platelet 5-HT concentrations in hypothyroid patients suggests a complex interaction between 5-HT system and HPT axis activity, which could be related to frequent occurrence of depressive symptoms in hypothyroid patients. The determination of platelet 5-HT concentration should be considered as a diagnostic tool for the evaluation of depressive symptoms in hypothyroid patients during hormone withdrawal procedure.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( POIROT)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( POIROT)
108-0362214-0127 - Korekcija gušenje zračenja u emisijskoj tomografiji srca (Dodig, Damir, MZOS ) ( POIROT)
214-1080058-0488 - PROGNOSTIČKI POKAZATELJI BIOLOŠKOG PONAŠANJA KARCINOMA ŠTITNJAČE (Bence-Žigman, Zdenka, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Stipčević, Tamara; Kusačić-Kuna, Sanja; Deželjin, Martina; Dodig, Damir; Koršić, Mirko; Pivac, Nela; Muck-Šeler, Dorotea
Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients // Hormone research, 71 (2009), 4; 207-212 doi:10.1159/000201109 (međunarodna recenzija, članak, znanstveni)
Stipčević, T., Kusačić-Kuna, S., Deželjin, M., Dodig, D., Koršić, M., Pivac, N. & Muck-Šeler, D. (2009) Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients. Hormone research, 71 (4), 207-212 doi:10.1159/000201109.
@article{article, year = {2009}, pages = {207-212}, DOI = {10.1159/000201109}, keywords = {Platelet 5-HT, Platelet MAO B, hypothyroidism, thyroxine, thyroid stimulating hormone}, journal = {Hormone research}, doi = {10.1159/000201109}, volume = {71}, number = {4}, issn = {0301-0163}, title = {Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients}, keyword = {Platelet 5-HT, Platelet MAO B, hypothyroidism, thyroxine, thyroid stimulating hormone} }
@article{article, year = {2009}, pages = {207-212}, DOI = {10.1159/000201109}, keywords = {Platelet 5-HT, Platelet MAO B, hypothyroidism, thyroxine, thyroid stimulating hormone}, journal = {Hormone research}, doi = {10.1159/000201109}, volume = {71}, number = {4}, issn = {0301-0163}, title = {Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients}, keyword = {Platelet 5-HT, Platelet MAO B, hypothyroidism, thyroxine, thyroid stimulating hormone} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font