engleski

The renal parenchyma evaluation : any advantage of MAG3 scans?

The purpose of this research was to assess the possibilities of using the initial phase of study with MAG3 for the evaluation of renal parenchyma. In 83 studied patients, 57 female and 26 male, of whom 34 children under the age of 15, scintiscans of the parenchymal phase of the study with MAG3 were compared with scintiscans in the same projection made with DMSA. The investigation was performed with the same gamma camera, under the exactly same conditions of detection. Three months was the longest period between the MAG3 and DMSA scans. The analysis was performed independently first with MAG3, applying strict evaluation criteria of the appearance of the outlines and the accumulation of radiopharmaceuticals in particular segments of each kidney. The analysis with DMSA was performed in exactly the same way and finally both studies were compared by simultaneous analysis. Results showed that in over 80% of cases scintiscans with MAG3 and DMSA correspond completely. The outlines of the kidneys were less distinct in the analysis with MAG3, so that in 20% of patients there was a suspect outline change, which was not visible on scintiscans with DMSA. Although DMSA produces sharper outlines and a superior quality presentation of the parenchyma, a clear outline defect or a parenchymal lesion visible on a scintiscan with DMSA could always be differentiated even when analysis was performed with MAG3. The differential function (ratio) of both radiopharmaceuticals also showed no significant differences. In obstructive renal disease MAG3 has prooved to be superior to DMSA because collecting system in this phase contains no radioactivity.

kidney;parenchyma;scintigraphy;MAG3;DMSA

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