engleski

Does breath-holding increase the risk of a thrombotic event?

The spleen contains about one third of total body platelets, which are relatively larger and hemostatically more active. Since voluntary apnea triggers splenic contraction we evaluated whether breath-holding impacts on circulating platelets. 18 trained divers and 24 untrained persons, 6 of whom had been splenectomized performed five successive maximal apneas, separated by 2 min periods. The venous samples, taken at baseline, immediately after each apnea and up to 60 min after the last apnea, were analyzed for platelet count, corrected for changes in total protein concentration, and mean platelet volume. Apneas did not affect platelet count, while the mean platelet volume increased significantly in trained divers, maximally for 9.3% (p=0.02), non-significantly in intact untrained persons (3.1%, p=0.1) and stayed unchanged in splenectomized persons. Breath-holding initiates the increase of large platelets in circulation. Hypothetically, these results can explain the increased risk of thromboembolic events in obstructive sleep apnea.

mean platelets volume; stroke; obstructive sleep apnea

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