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Synthesis and structural character-ization of metallated bioconjugates: C-terminal labeling of amino acids with ferroceneamine


Jios, Jorge L.; Buceta, Norma N.; Kirin, Srećko I.; Metzler-Nolte, Nils; Della Vedova, Carlos O.; Weyhermüller, Thomas
Synthesis and structural character-ization of metallated bioconjugates: C-terminal labeling of amino acids with ferroceneamine // Proceedings of ECSOC-10, The Tenth International Electronic Conference on Synthetic Organic Chemistry / Seijas, Julio A. ; Vazquez-Tato, M. Pilar (ur.).
Basel: MDP International, 2006. str. c013/1-c013/10 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


Naslov
Synthesis and structural character-ization of metallated bioconjugates: C-terminal labeling of amino acids with ferroceneamine

Autori
Jios, Jorge L. ; Buceta, Norma N. ; Kirin, Srećko I. ; Metzler-Nolte, Nils ; Della Vedova, Carlos O. ; Weyhermüller, Thomas

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of ECSOC-10, The Tenth International Electronic Conference on Synthetic Organic Chemistry / Seijas, Julio A. ; Vazquez-Tato, M. Pilar - Basel : MDP International, 2006, C013/1-c013/10

ISBN
3-906980-18-9

Skup
The Tenth International Electronic Conference on Synthetic Organic Chemistry

Mjesto i datum
Internet, 01.-30.11.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Amino acids; bioorganometallic chemistry; ferrocene; peptides; X-ray

Sažetak
Ferroceneamine, H2N-Fc, has been substituted to the C-terminus of 6 amino acids using the HBTU / HOBt coupling protocol. The synthesized bioconjugates Boc-Aaa-Fc, Aaa = Gly (1), Leu (2), Phe (3), Val (4), Cys(Acm) (5), Tyr(tBu) (6) (Acm = acetamidomethyl, tBu = t-buthyl), have been characterized by 1H NMR, 13C NMR EI-MS, EI-HRMS, UV and CD spectroscopies. In addition, a VT NMR study on 4 and the X-ray structure of 1 are presented.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Autor s matičnim brojem:
Srećko Kirin, (192540)