engleski

DRB1*15 versus DRB1*03 and DRB1*13: Influence on chronicity in Croatian sarcoidosis patients

Various genetic and environmental factors have been implicated in the development of sarcoidosis. HLA-DRB1*15 has been proposed as a marker of disease chronicity in Irish ad HLA-DQB1*0602-DRB1*150101 of poor outcome in Dutch sarcoidosis patients, but validation in other ethnic groups is necessary. We have tested 134 Croatian sarcoidosis patients and 285 ethnically-matched controls for HLA-DRB1 specificities by PCR-SSP method. Diagnosis of sarcoidosis was based on consistent clinical features, together with biopsy-proven noncaseating epitheloid cell granulomas. All patients were followed up for 2-18, average 4.5 years. The follow up armamentarium included the clinical examination, chest X ray, pulmonary function measurements, and other tests to evaluate the course of extrapulmonary sarcoidosis, if present. At the end of follow up period 40 patients (29.85%) had chronic sarcoidosis while the remaining 94 subjects showed no sign of sarcoidosis. DRB1*03 specificity was significantly less prevalent among patients with chronic (15.0%) in comparison to patients with acute sarcoidosis (32.9%) (P=0.0363). DRB1*13 specificity was present among only 3 patients (7.5%) who developed chronic sarcoidosis. This specificity was present among 56 control subjects (19.65%) and 21 patients (22.3%) with acute sarcoidosis (P=0.0416 and P=0.0489, respectively). DRB1*15 was significantly more frequent among patients with chronic sarcoidosis (32.5%) than among controls (16.49%) as well as among patients with acute sarcoidosis (23.4%) (P=0.0260 and P=0.0173, respectively). This study suggests the association of DRB1*03 and DRB1*13 specificity with lower risk for developing chronic sarcoidosis. Conversely, DRB1*15 is a marker of worse prognosis and predicts disease chronicity in Croatian sarcoidosis patients.

sarcoidosis; HLA genes

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