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Effect of L-Carnitine Supplementation on Some Biochemical Parameters in Blood Serum of Sedentary Population


Delaš, Ivančica; Dražić, Tonko; Čačić-Hribljan, Melita; Sanković, Krešimir
Effect of L-Carnitine Supplementation on Some Biochemical Parameters in Blood Serum of Sedentary Population // Croatica Chemica Acta, 81 (2008), 1; 163-168 (međunarodna recenzija, članak, znanstveni)


Naslov
Effect of L-Carnitine Supplementation on Some Biochemical Parameters in Blood Serum of Sedentary Population

Autori
Delaš, Ivančica ; Dražić, Tonko ; Čačić-Hribljan, Melita ; Sanković, Krešimir

Izvornik
Croatica Chemica Acta (0011-1643) 81 (2008), 1; 163-168

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
L-carnitine; body mass reduction; sedentary population; free fatty acids

Sažetak
Because of its role in a transport of fatty acids from cytosol into mitochondrion, a consumption of L-carnitine became popular among athletes, and/or as a weight loss supplement. In an attempt to obtain more data on the effect of L-carnitine supplementation on some biochemical parameters in blood serum, a double-blind, placebo-controlled study was carried. Healthy volunteers with declared sedentary activities received 2 g/day of either L-carnitine or placebo for 2 weeks. L-carnitine administration induced no statistically significant changes in blood serum concentrations of glucose, triacylglycerols, total cholesterol, HDL-cholesterol and creatinine, neither affected the activity of analysed enzymes (AST, ALT, LDH, and CK). The only observed effect was a decline in the concentration of free fatty acids in serum from 0.439 mmol/L at the beginning to 0.279 mmol/L at the end of the experiment. Body mass reduction was not achieved. We conclude that L-carnitine supplementation cannot be used for body mass reduction per se, but might be involved in energy utilisation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija, Prehrambena tehnologija



POVEZANOST RADA


Projekt / tema
0108068

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinika za dječje bolesti Medicinskog fakulteta,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus