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Bone marrow involvement and the prognosis of low grade non-Hodgkin's lymphoma

Aim: To analyze the bone marrow (BM) infiltration in low-grade non-Hodgkin's lymphomas (LGNHL) and assess its association with the histopathology type, clinical behavior, and disease prognosis. Method: BM smears obtained by needle biopsy and stained by standard methods were analyzed in 60 patients with LGNHL using the Working Formulation. Results: BM infiltration was observed in 57% of the lymphocytic lymphomas (A), in 48% of lymphoplasmocytic/ plasmocytoid lymphomas (AI), and in 31% of follicular lymphomas (follicular small cleaved cell and follicular mixed B and C). The difference was not significant. The 5-year survival rates for patients with and without bone marrow infiltration were 53% and 56% respectively, and 10-year survival rates were 31% and 45% (p>0.05). Conclusion: The presence of bone marrow infiltration at diagnosis did not significantly affect the prognosis of LGNHL.

bone marrow; chemotherapy; lactate dehidrogenase; non-Hodgkin lymphoma

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