engleski

Prognostic Value of Histological Gradus in Ovarian Cancer

Aim: To determine the connection between histological gradus defined by Silverberg histological score and survival in patients with ovarian cancer. Materials and methods: In this study, he surgical material of 80 patients with surface epithelial stromal carcinoma of the ovary was examined. Histological gradus was defined by histological score. The tumor architecture, the characteristics of a nucleus and the number of mitoses were analyzed on 10 HPF. Survival data were gained from the history of the patients treated in the department of Oncology, Clinical Hospital Split. Survival data were analyzed by life-tables and graphically presented by Kaplan-Meier curves. Results: Silverbergs and collaborators distinguish three histological gradus of ovarian cancer: high (3-5), medium (6-7) and low (8-9). Regarding the tumors with medium histological gradus (histological score 6-7) observed in this study, statistically significant survival difference was found between the patients with histological score 6 and those with histological scor 7 (p=0.05). Tumors with histological score 7 behave as low gradus tumors. Tumors with histological score 6 behave as high gradus tumors. According to the study results, the patients were divided into two groups: a group with low (7-9) and a group with high (3-6) histological gradus. Out of 80 patients included in the study, 40 (50%) were placed in high (3-6) and 40 in low (7-9) gradus group. We found statistically significant connection between histological gradus and survival (p<0, 0001). Conclusion: New grading system is simple, highly reproducible and applicable to all histological types of tumor. To best of our knowledge, we didn´t find any data published in the recent literature regarding distinguishment of survival within the medium gradus (prognosticaly ill defined) group, so we hope that the results of this study which help to distinguish two tumor risk groups, could be encouragement for further research in this field.

Ovarian cancer; Histological gradus; Survival

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