engleski

Oral lichenplanus and HLA DR

Oral lichen planus (OLP) is a chronic inflammatory mucocutaeous disease, predominntly seen in middle-aged female patients. Histopathologically, OLP includes parakeratosis with T-lymphocite subepithelial infiltration. In the etiology of OLP, chronically liver and billiary diseases, stress-induced hypertension, inheritance and most commonly carbohydrate metabolism disorders including diabetes mellitus are mentioned. Considering the autoimune nature of the illness and the role of the HLA DR 3/4 antigenes in development of diabetes mellitus we hypothesized that the same antigenes could play role in the development of OLP. We examined 50 unrealated Croatian patients (5 males) from Institute of Oral Pathology, Faculty of Dental Medicine, Zagreb, with clinical and histopathological diagnosis of OLP. They were all tested for HLA DR and compared with 1089 Croatian s that underwent the tissue standardization in fathership cases. OLP patients had blood sugar level controlled, and those with HLA DR3/4 and those with blood sugar level higher than 5, 6 mmol/l additionally underwent standard oral glucose tolerance test. Carbohydrate metabolism disorders was found in 13 OLP patients (226%) while 10 of them (20%) had diabetes mellitus type 1. This finding is 400 times more frequent than is appearance of diabetes in healthy controls (0, 05%) in Croatia.

Oral lichen planus; HLA DR

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