engleski

Electrochemical study of phospholipid monolayer-model lipids interfacial interactions

Electrochemical impedance spectroscopy, ac voltammetry and fractal analysis were used to characterise interaction of model water insoluble compounds of increasing polarity with phospholipid monolayer. The mercury drop electrode uncoated and coated with a monolayer of dioleoyl phosphatidylcholine (DOPC) was used as a basis for investigation. The compounds studied in order of increasing polarity were: nonadecane, stearic acid, cholesterol and cardiolipin. From the electrochemical response, it is observed that both the molecular structure and polarity of the investigated compounds have a role in their interaction with the uncoated and DOPC coated electrode. In the fractal analysis the degree of fractal dimension D imparted to the DOPC layer is related to the degree of apolarity of the additive model compound.

dioleoyl phosphatidylcholine; model lipids; impedance spectroscopy; ac voltammetry; fractal analysis

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