engleski

Tuning urea-phenanthridinium conjugates for DNA/RNA and basepair recognition

A series of novel urea-phenanthridine conjugates was prepared. The variation of linker length connecting two urea-phenanthridinium conjugates regulated their binding mode toward double stranded polynucleotides, consequently controlling selectivity of compounds toward ds-RNA over ds-DNA stabilisation as well as selective fluorescence response toward addition of G-C basepair and A-U(T) basepair containing polynucleotides.

urea-phenanthridinium ; DNA/RNA selectivity ; fluorescence selectivity ; intercalation ; groove agglomeration

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