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Tuning urea-phenanthridinium conjugates for DNA/RNA and basepair recognition


Radić Stojković, Marijana; Piantanida, Ivo
Tuning urea-phenanthridinium conjugates for DNA/RNA and basepair recognition // Tetrahedron, 64 (2008), 33; 7807-7814 doi:10.1016/j.tet.2008.05.142 (međunarodna recenzija, članak, znanstveni)


Naslov
Tuning urea-phenanthridinium conjugates for DNA/RNA and basepair recognition

Autori
Radić Stojković, Marijana ; Piantanida, Ivo

Izvornik
Tetrahedron (0040-4020) 64 (2008), 33; 7807-7814

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Urea-phenanthridinium; DNA/RNA selectivity; fluorescence selectivity; intercalation; groove agglomeration

Sažetak
A series of novel urea-phenanthridine conjugates was prepared. The variation of linker length connecting two urea-phenanthridinium conjugates regulated their binding mode toward double stranded polynucleotides, consequently controlling selectivity of compounds toward ds-RNA over ds-DNA stabilisation as well as selective fluorescence response toward addition of G-C basepair and A-U(T) basepair containing polynucleotides.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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