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Lead interference in zinc metabolism and the lead and zinc interaction in humans as a possible explanation of apparent individual susceptibility to lead (CROSBI ID 539559)

Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija

Telišman, Spomenka ; Pizent, Alica ; Prpić-Majić, Danica Lead interference in zinc metabolism and the lead and zinc interaction in humans as a possible explanation of apparent individual susceptibility to lead // Heavy Metals in the Environment / Allan RJ, Nriagu JO (ur.). Edinburgh: CEP Consultants, 1993. str. 404-407

Podaci o odgovornosti

Telišman, Spomenka ; Pizent, Alica ; Prpić-Majić, Danica

engleski

Lead interference in zinc metabolism and the lead and zinc interaction in humans as a possible explanation of apparent individual susceptibility to lead

Serum zinc (ZnS), seminal fluid zinc (ZnF), blood lead (PbB), and activity of erythrocyte delta-aminolevulinic acid dehydratase (ALAD) were measured in 152 adult male subjects, not occupationally exposed to zinc: 101 lead workers with long-term slight to moderate occupational lead exposure and 51 control subjects with no occupational lead exposure. Significant correlations were found between a decrease of ZnS with respect to an increase of PbB (r=-0.135, P<0.05) and a decrease of ALAD (r=0.237, P<0.002), between a decrease of ZnF with respect to PbB (r=-0.245, P<0.001) and ALAD (r=0.262, P<0.001), and between ZnS and ZnF (r=0.255, P<0.001). The results indicate possible lead interference in zinc metabolism resulting in relative zinc deficiency, and thus lead-zinc interaction which can influence ALAD as well as some other lead-related effects. This might explain a large part of the interindividual differences in response to the same PbB level, i.e. apparent individual susceptibility to lead, which was ascribed to genetic factors.

blood lead; serum zinc; seminal zinc

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Podaci o prilogu

404-407.

1993.

objavljeno

Podaci o matičnoj publikaciji

Heavy Metals in the Environment

Allan RJ, Nriagu JO

Edinburgh: CEP Consultants

0 905941 51 9

Podaci o skupu

9th International Conference on Heavy Metals in the Environment

predavanje

12.09.1993-16.09.1993

Toronto, Kanada

Povezanost rada

Javno zdravstvo i zdravstvena zaštita