engleski

IL1beta promoter polymorphisms - association with cerebral palsy

Introduction: Cerebral palsy (CP) is a nonprogressive motor disorder caused by white matter damage in the developing brain. It is often accompanied with neurocognitive and sensory disabilities. The cause and pathogenesis of CP is multifactorial and continues to be poorly understood. Chorioamnionitis, clinically silent or manifest, has been reported to be a risk factor for CP both in term and preterm infants. IL1beta gene was mapped to chromosome 2q14 and a few polymorphisms associated with altered IL1beta production have been described. Increased IL1beta levels have been found in peripheral blood in septic neonates and can be associated with the development of cerebral palsy. The aim of our study was to estimate allelic frequency for two promoter SNPs in IL1beta gene, -31 and -511 in the children with the CP. Methods: DNAs obtained from peripheral blood of 41 CP patients and 162 unrelated healthy volunteers were genotyped for the IL1beta -31 and -511 SNP using real-time PCR TaqMan&reg ; SNP genotyping assays. Results and Conclusion: IL1beta  allele variant -31C and -511T were more common in the population with cerebral palsy in the comparison to healthy volunteers. The significance of the association between IL1beta  gene polymorphisms and cerebral palsy has to be investigated in the future studies.

IL1beta; SNPs; cerebral palsy

nije evidentirano