engleski

MICROALBUMINURIA AND DIABETES MELLITUS

In diabetic patients with proteinuria the relative mortality is about 40 times higher than in diabetics without proteinuria. Renal damage is a serious complication of diabetes mellitus (DM). It is estimated that death due to renal disease is 17 times more common in diabetics than in nondiabetics. Diabetic nephropathy is the most important cause of death in type 1 diabetic patients, of whom 30%-40% eventually develop end-stage renal failure. Death due to diabetic nephropathy with renal failure is less common in type 2 DM. The relative risk of renal mortality in diabetic patients diagnosed after the age of 45 years is estimated to be twofold that in nondiabetic patients. However, proteinuria as an indicator of renal involvement is not uncommon in patients with type 2 DM. It is now established that in both type 1 and 2 DM, urinary excretion of small amounts of albumin (microalbuminuria) is predictive of morbidity and mortality due to renal complications and cardiovascular disease.

microalbuminuria; diabetes mellitus; nephropathy

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