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Register of congenital heart defects (CHD) in Croatia (Croatian study -October 2002. – January 2007.)

Introduction: Since 1979 congenital heart defects (CHD) have been followed in Europe by EUROCAT study (European Registry Of Congenital Anomalies and Twins). EUROCAT study is population register of CHD based on 21 regional center in 11 european countries and includs 240 000 labors per year. We formed Register of CHD in Croatia on EUROCAT study model because of high quality of their pattern and our goal to be part of EUROCAT study some time in the future. It is formed not only as population register but also as hospital register that includes details of patient diagnoses, treatment and enables us to make life -survival curves. Methods: We formed the Register including all children with CHD treated in 15 Departments of paediatrics in Croatia, born since December 2002 as a prospective study according to EUROCAT study model. Results: Since December 2002, 1492 children with congenital heart defect was recognized, female 719 (48 %) and 773 (52 %) male. According to anamnestic data 4% of them was born from pregnancy complicated with acute infection, 2% from mothers with chronic diseases (diabetes mellitus, epilepsy, mesenhymopathias), 2% have CHD in family and 2% other inherited diseases. Out of 1492 children 432 (29 %) had ventricular septal defect, 334 (22%) atrial septal defect, 167 (11.2%) patent aterial duct, 80 (5.4%) pulmonary valve stenosis, 35 (2.3%) aortic valve stenosis, 36 (2, 4%) tetralogy of Fallot, 44 (2.9%) transposition of great arteries, 48 (3.2%) coarctation of the aorta, 48 (3.2%) atrioventricular canal, 25 (1.7%) hypoplastic left heart syndrome, 22 (1.5 %) cardiomiopathies, 50 (3.4%) arrhythmias and 60 (4.1%) complex heart malformations or deformations. Operation underwent 273 (18.3%), 256 (17.2%) was treated only medicamentously. Extracardiac anomalies was recognized in 206 (13.8%) children and among them 73 (35.4%) with Down syndrome. Only 32 (2.1%) were diagnosed prenataly. During follow up 43 (2.9%) children died (17 of them were operated). Conclusion: The incidence of CHD in Croatia (8 0/00) corelates to world data as well as the most common diagnoses, VSD followed by ASD. The aim of Register is to establish base for follow up of children with CHD for whole country.

Register; congenital heart defects; Croatia

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