engleski

The role of viruses in reproduction and aneuploidy

Abnormal centrosome duplication is tightly linked to aneuploidy. Spontaneus abortions appear with incidence of 12-15% in population. In spontaneous abortions there are 25-60% of chromosome abnormalities, and in most cases there are triploidies, tetraploides and polyploides. A retrospective analysis was done over 500 couples with one or more spontaneous abortion and 296 parafin embeded samples werw found. 41 placentas was analysed by flow: 66% diploid and 34% aneuploid. 30% had IgM or/and IgG for EBV and 4% for CMV. HPV positive diploid paraffin embedded sample from one couple with three consecutive spontaneous abortions was found.

viruses; reproduction; aneuploidy

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