engleski

N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new chelator of iron in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg-1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas in female rats (1.5 mg kg-1 body mass) the iron value dropped for 32%. Results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.

N-phthaloyl-glycine-hydroxamic acid ; iron chelators ; iron overload

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